Reproduction Abstracts

Lysophosphatidic acid (LPA) is a simple phospholipid and exerts various biological functions effecting on reproductive processes in rats, pigs, ewes and cow. LPA acts through three subtypes of Edg family G protein-coupled receptors (LPA1-3) and ‘non-Edg family’ LPA receptors (LPA4-6). The aim of the study was to determine LPA: i) concentrations and its receptors mRNA transcription, and ii) effect on P4 secretion from equine CL during the oestrous cycle and...

In cow, lysophosphatidic acid (LPA) stimulated synthesis and secretion of luteotropic factors in ovary, which affected growth and development of ovarian follicles. Theca cells, among other components of ovarian follicle, play an essential role in ovulation, which depends on intrafollicular prostaglandin synthesis. In bovine reproductive tract, modulation of prostaglandin synthesis occurs under influence of LPA. Thus, the aim of this study was to determine possible correlation ...

Mural granulosa cells participate in development and differentiation of ovarian follicle. In bovine reproductive system, LPA is involved in autocrine and paracrine signaling, through LPA receptors (LPAR)s. We demonstrated before that LPA modulated prostaglandin (PG) synthesis in uterus and ovary and stimulated estradiol (E2) synthesis in granulosa cells in bovine follicle. As the ovarian follicle development and differentiation leading to oocyte ovulation depend on ...

Introduction: In the absence of pregnancy, the resumption of a new estrous cycle is assured by functional and structural regression of the corpus luteum (CL). We have recently characterized the involvement of Nodal, a morphogen from transforming growth factor beta superfamily, on functional luteolysis in the mare (Galvao et al, 2015 Endocrinology, 157:858–871). Also, tumor necrosis factor α (TNF) has been reported to mediate both functional and structural luteal regr...